Fc-gamma receptors (FcγRs) expressed on the surface of immune effector cells play a key role in initiating Fc effector functions like antibody-mediated cell-dependent cytotoxicity (ADCC). The binding of therapeutic antibodies to FcγRs can greatly impact their safety and efficacy. From early ... mehr
Best Practices for Large Molecule Kinetic Assays on the Octet System
Label-free analytical technologies such as the Octet® system provide a powerful means to obtain information about biomolecular binding interactions and kinetics, key components of a drug-target interaction. However, there are many practical considerations involved in producing consistent, high quality kinetic binding profiles from biological samples. In this webinar, we will review large molecule kinetic analysis on Octet platform and discuss tips, techniques and considerations for developing and running successful kinetic characterization assays and interpreting results.