Label-free analytical technologies such as the Octet® system provide a powerful means to obtain information about biomolecular binding interactions and kinetics, key components of a drug-target interaction. However, there are many practical considerations involved in producing consistent, h ... mehr
One Step Ahead for Fragment Screening
Fragment-based drug discovery requires throughput to process a large number of samples while maintaining sensitivity for low molecular weight analytes and weak affinity interactions. The Pioneer FE system offers a unique and rapid solution for biomolecular kinetics characterization and small molecule drug discovery. A key component of the Pioneer system is a proprietary gradient injection technology that enables rapid and more information-rich analysis of kinetic interactions, allowing for affinity data to be obtained during primary screens. This technology is called dynamic injection SPR (diSPR) and is utilized by the Pioneer systems for simplified, direct measurement of kinetic rate constants and for competition and inhibition assays.
This webinar will provide an overview of the Pioneer platform from Pall ForteBio, including its unique OneStep and NextStep single-injection features for accelerating label-free characterization. Applying the Pioneer systems across a range of biomolecular interaction kinetics and fragment screening applications will also be discussed.